2-Chlorophenylboronic Acid CAS 3900-89-8: Specifications, Uses, and Supplier Guide

2-Chlorophenylboronic acid, CAS 3900-89-8, is an aryl boronic acid used primarily as a building block in palladium-catalyzed cross-coupling, especially Suzuki–Miyaura reactions. Its molecular formula is C₆H₆BClO₂, and its calculated molecular weight is approximately 156.38 g/mol. I recommend evaluating this material through its identity, assay, water content, impurity profile, packaging, and batch-specific documentation rather than relying only on the product name.

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At Maison Chemical, I support B2B buyers with sourcing and technical information for organic boronic acids, including inquiry-based confirmation of specification, packaging, documentation, and delivery requirements. Because actual assay, appearance, residual solvents, and lead time can vary by batch and production route, I treat the supplier specification and certificate of analysis (COA) as the controlling documents for procurement.

Who This Guide Is For

This guide is intended for pharmaceutical and agrochemical research teams, medicinal chemistry laboratories, process-development groups, contract research organizations, and chemical distributors evaluating 2-chlorophenylboronic acid. It is also useful for purchasing teams that need to compare technical suitability before requesting a quotation. The material may be considered for laboratory-scale synthesis, route screening, process studies, or commercial intermediate sourcing, subject to the buyer’s own qualification procedures.

I focus here on the information that normally affects a purchase decision: chemical identity, reaction role, expected specification categories, application matching, supplier evaluation, and commercial factors. I do not present a universal purity, melting point, shelf life, or delivery time because those values must be confirmed against the specific manufacturer’s current COA, SDS, and quotation.

Basic Chemical Context and Identity

2-Chlorophenylboronic acid contains a boronic acid group attached to a chlorinated phenyl ring. The boronic acid functionality can participate in carbon–carbon bond-forming reactions, while the chlorine substituent remains available for further synthetic planning or may influence the electronic and steric behavior of the aromatic substrate.

The CAS Registry Number is 3900-89-8. The molecular formula is C₆H₆BClO₂, and the calculated molecular weight is approximately 156.38 g/mol; therefore, 1.00 mmol corresponds to approximately 156.38 mg before accounting for purity or water content. PubChem provides a useful independent identity reference, but buyers should still reconcile the supplier’s product data with their internal material master and analytical results. Source: PubChem, National Library of Medicine.

Calculated Composition as a Useful Check

From the stated molecular formula, the approximate theoretical chlorine contribution is 22.7% by mass and the boron contribution is approximately 6.9% by mass. These are calculated values, not assay results, and they should not replace chromatographic, spectroscopic, or elemental analysis. I use them only as basic plausibility checks when reviewing identity information.

Specifications Buyers Should Review

A practical purchase specification should distinguish identity requirements from quality limits. For identity, I normally request the CAS number, molecular formula, molecular weight, structural confirmation, and analytical method used for identification. For quality, I ask the supplier to state the assay basis, impurity limits, water content, residual solvent limits, and any applicable appearance requirement.

For regulated or customer-controlled projects, I recommend defining acceptance criteria before placing the purchase order. A specification such as “high purity” is not sufficiently precise unless the buyer and supplier agree on the analytical method, reporting basis, and impurity thresholds. The International Council for Harmonisation emphasizes the importance of scientifically justified specifications and validated analytical procedures in pharmaceutical quality systems. Source: ICH Quality Guidelines.

Uses and Application Matching

Suzuki–Miyaura Cross-Coupling

The most common synthetic role of 2-chlorophenylboronic acid is as an aryl-boron coupling partner in Suzuki–Miyaura chemistry. In a typical reaction design, the boronic acid reacts with an aryl or vinyl halide under a suitable palladium catalyst, base, solvent, and temperature profile to form a new carbon–carbon bond. The exact conversion depends on substrate electronics, catalyst selection, base compatibility, water content, reaction concentration, and work-up conditions.

For process development, I recommend screening the compound with a defined equivalent range rather than assuming that a literature procedure will transfer directly. A useful starting design may compare 1.0–1.5 equivalents of the boronic acid, several base systems, and catalyst loading appropriate to the project; these are screening parameters, not guaranteed operating conditions. Buyers should establish the final reaction conditions through their own laboratory or process evaluation.

Medicinal Chemistry and Intermediate Synthesis

The compound can be relevant when a target structure requires an ortho-chlorinated biaryl or related aryl framework. The chlorine substituent may be retained in the product for later transformation, used to influence molecular design, or simply serve as part of the final pharmacophore. Suitability depends on the target route, tolerance of the remaining functional groups, and the project’s impurity-control strategy.

It may also be used in route scouting for pharmaceutical, agrochemical, and specialty organic synthesis. However, I do not recommend treating the presence of a boronic acid group as proof of universal compatibility with every coupling partner. Some substrates may undergo protodeboronation, catalyst poisoning, incomplete conversion, or difficult product purification.

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Types, Material Options, and Supply Forms

When sourcing this product, the main commercial differences are usually not different chemical “grades” in a universal sense, but rather supplier-defined purity levels, packaging sizes, documentation packages, and quality-control methods. A laboratory pack may be suitable for feasibility work, while a larger project may require multiple lots, controlled packaging, and pre-agreed release criteria. I advise buyers to specify whether they need research-use material, process-development material, or a material subject to a formal quality agreement.

Some boronic acids may be supplied as powders with varying appearance, particle characteristics, or moisture levels. I do not assume that appearance alone confirms quality, and I do not use an unverified melting point or solubility value as a purchase guarantee. If particle size, bulk density, dissolution time, or milling is important to the process, those requirements should be written into the inquiry and technically reviewed before quotation.

Buyer Selection Framework

1. Define the Intended Use

First, identify whether the material is for reaction screening, analytical reference, process development, scale-up, or distribution. The intended use determines how much documentation, lot consistency, and technical support may be necessary. A small exploratory order and a repeat commercial supply should not be evaluated by exactly the same criteria.

2. Set the Quality Requirement

Next, define the minimum assay, impurity limits, water limit, packaging format, and required analytical methods. If the project has a downstream filing or customer audit requirement, request representative documentation before purchase rather than after delivery. I also recommend identifying whether the buyer requires a specific origin, change-notification process, or retained sample policy.

3. Check Logistics and Handling

Confirm net weight, number of containers, shipping classification, export documents, and storage instructions from the current SDS. The United States Occupational Safety and Health Administration requires hazard communication through labels and safety data sheets for applicable hazardous chemicals, so an SDS should be part of the supplier review. Source: U.S. OSHA Hazard Communication Standard.

4. Compare Total Sourcing Risk

Price per kilogram is only one part of the decision. I also compare documentation quality, response time, lot availability, packaging suitability, import requirements, replacement policy, and the supplier’s ability to maintain the agreed specification. A slightly lower price may not be advantageous if the buyer faces repeated analytical deviations, delayed documents, or an uncertain replenishment plan.

Pricing, MOQ, and Lead Time Considerations

Pricing for 2-chlorophenylboronic acid generally depends on requested quantity, purity target, packaging, analytical documentation, production status, destination, and delivery terms. Minimum order quantity (MOQ) and lead time are therefore quotation-specific rather than fixed product attributes. For an accurate commercial assessment, I recommend sending the required quantity, destination country, target specification, packaging preference, and desired delivery date together in the first inquiry.

For repeat programs, buyers may benefit from discussing a forecast, staggered deliveries, or multiple-lot qualification. These arrangements can improve planning, but they should not be assumed to guarantee a fixed price or uninterrupted availability without a written supply agreement. Maison Chemical can review the request and confirm which specifications, documents, packaging options, and delivery arrangements are available for the requested volume.

Common Procurement Mistakes

• Using the CAS number alone without checking the structural formula and supplier identity data.
• Accepting an unspecified “technical grade” when the project requires a defined assay and impurity profile.
• Ignoring water content or residual solvents in a moisture-sensitive or tightly controlled reaction.
• Requesting a quotation without stating destination, quantity, packaging, or documentation needs.
• Assuming a published literature procedure will deliver the same conversion at a different scale.
• Failing to review the SDS before arranging storage, handling, or international shipment.

Supplier Evaluation Checklist

Before selecting a supplier, I recommend requesting a current COA, SDS, product specification, sample availability, packaging details, and a clear quotation validity period. For technically sensitive projects, ask whether the supplier can provide batch-to-batch analytical support and whether a pre-shipment document review is possible. If the material will enter a regulated process, also clarify change-control, traceability, and complaint-handling procedures.

Maison Chemical approaches this product as a B2B sourcing request rather than a simple catalogue transaction. I can help organize the technical inquiry around CAS 3900-89-8, requested assay, quantity, destination, packaging, and documentation requirements, while keeping final acceptance subject to the buyer’s approved specification and testing process. This approach is more reliable than making unsupported claims about universal purity, fixed inventory, or guaranteed delivery.

Key Takeaways

• 2-Chlorophenylboronic acid is an aryl boronic acid identified by CAS 3900-89-8.
• Its formula is C₆H₆BClO₂, with a calculated molecular weight of approximately 156.38 g/mol.
• Its principal value is as a building block for Suzuki–Miyaura and related carbon–carbon bond-forming chemistry.
• Assay, impurity profile, water content, packaging, COA, and SDS should be reviewed before purchase.
• Price, MOQ, and lead time depend on quantity, specification, destination, and current supply conditions.

Conclusion and Next Steps

2-Chlorophenylboronic acid CAS 3900-89-8 is generally selected when a synthetic route requires an ortho-chlorinated aryl boronic acid for carbon–carbon bond formation or related intermediate preparation. The right purchasing decision depends on more than the chemical name: buyers should confirm identity, analytical quality, moisture and impurity controls, documentation, packaging, and logistics. I recommend qualifying the material against a project-specific specification before moving from laboratory screening to repeat or larger-volume supply.

To request a quotation from Maison Chemical, provide the required quantity, target assay, destination, packaging preference, intended application, and documentation requirements. I can then help structure the inquiry and confirm the available supply solution, commercial terms, and batch-specific documents for your evaluation.