3,4,5-Trifluorophenylboronic Acid CAS 143418-49-9: Supplier, Purity, COA, SDS, and Bulk Buying Guide

I use this guide to help procurement, R&D, and quality teams evaluate 3,4,5-trifluorophenylboronic acid, also identified by CAS 143418-49-9, before placing a laboratory, pilot-scale, or bulk order. The material is an organoboron intermediate commonly considered for palladium-catalyzed cross-coupling and related synthetic development. When I evaluate a purchase, I do not rely on the product name alone: I confirm identity, assay or purity, appearance, batch documentation, packaging, and shipping requirements with the supplier. Maison Chemical can support customers with product information, COA review, SDS documentation, quotation, and supply coordination according to project requirements.

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Key Takeaways for Buyers

• 3,4,5-Trifluorophenylboronic acid is an aromatic boronic acid used as a building block in synthetic chemistry, especially where a trifluorinated aryl group is required.
• The commonly listed molecular formula is C₆H₄BF₃O₂, with a molecular weight of approximately 175.91 g/mol; I recommend confirming these details against the supplier’s current specification.
• A reliable purchasing decision should include a lot-specific COA, an applicable SDS, clear packaging information, and written confirmation of available quantity and lead time.
• For bulk buying, I recommend comparing not only price per kilogram but also documentation quality, batch consistency, logistics, storage guidance, and the supplier’s ability to support repeat orders.

What Is 3,4,5-Trifluorophenylboronic Acid?

3,4,5-Trifluorophenylboronic acid is an aryl boronic acid containing a phenyl ring substituted with three fluorine atoms and a boronic acid group. Its CAS Registry Number is 143418-49-9, which provides a useful identity reference when I compare quotations, technical documents, and import or export paperwork. The material is generally handled as a specialty organic intermediate rather than as a finished pharmaceutical ingredient.

Its boronic acid functionality makes it relevant to synthetic routes that form carbon-carbon bonds, including Suzuki-Miyaura coupling when the reaction and substrate combination are technically suitable. The trifluorinated aromatic structure can also be selected during medicinal chemistry, agrochemical research, and advanced intermediate development when fluorine substitution is part of the target design. Actual suitability depends on the reaction conditions, catalyst system, substrate, and the customer’s validated process.

Basic Product and Specification Overview

In practice, I treat the table as an identification starting point, not as a substitute for a lot-specific specification. Different suppliers may define acceptance criteria differently, particularly for assay, water content, residual solvents, particle form, and analytical methods. Before approving a material for a controlled project, I ask for the current specification and representative or actual batch documentation.

How I Evaluate Purity and the COA

Purity and Analytical Results

Purity is one of the first commercial questions buyers ask, but the reported number must be interpreted together with the test method and sample information. I request the exact assay or purity value, the analytical technique used, the tested batch number, test date, and specification limit. A high stated purity does not by itself confirm that the material is suitable for every reaction, because trace moisture, residual solvents, inorganic residues, or decomposition products may affect a sensitive process.

For a typical COA review, I look for product name, CAS number, batch or lot number, manufacturing date when available, retest or expiry information when applicable, appearance, identification, assay, and release status. Depending on the application, I may also request water content, residual solvent data, elemental or inorganic impurity information, and chromatographic details. I do not recommend accepting an undated or untraceable document as the sole basis for a bulk release decision.

What a Useful COA Should Show

• A clear connection between the COA and the supplied lot number.
• The tested parameter, acceptance limit, actual result, and analytical method where applicable.
• Consistent product naming and CAS identification across all documents.
• Supplier identification, document date, authorized approval, or equivalent quality release information.
• Storage or retest guidance that is consistent with the product label and SDS.

How I Review the SDS and Shipping Information

The SDS is important for safe handling, storage, workplace assessment, and transport planning. I review the hazard classification, recommended personal protective equipment, first-aid measures, accidental-release guidance, firefighting information, handling and storage instructions, exposure controls, physical and chemical properties, stability, toxicological information, disposal guidance, and transport sections. The SDS should correspond to the actual product and current regulatory requirements for the destination market.

I also ask how the product is packaged and labeled before confirming an order. Common purchasing variables include container size, inner sealing, protective packaging, desiccant use where appropriate, outer carton configuration, and whether the product requires special temperature or humidity control. I avoid assuming that a standard package is suitable for long-term storage or international transit without written confirmation from the supplier.

Matching Product Grade to the Application

For early-stage research, a standard research or synthesis grade may be sufficient when the customer’s internal method tolerates normal specification ranges. For process development, I usually recommend defining critical quality attributes before increasing the order size. These may include assay, impurity profile, water content, physical form, solubility behavior, and lot-to-lot consistency.

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For regulated or tightly controlled programs, the buyer should communicate the intended use before quotation. The supplier may need to review documentation expectations, change-control requirements, sample retention, packaging, and repeat-batch availability. I do not describe a product as pharmaceutical grade, GMP grade, or compliant with a specific regulation unless the relevant documentation and manufacturing conditions have been verified for that product.

Bulk Buying: Price, MOQ, and Lead Time

Bulk pricing for 3,4,5-trifluorophenylboronic acid depends on requested quantity, available inventory, production schedule, packaging, testing requirements, destination, and shipping terms. I recommend requesting at least three commercial quantities, such as laboratory scale, pilot scale, and planned production quantity, rather than asking only for a single price. This helps reveal whether the quoted price changes because of volume, packaging, testing, or a different production batch.

Minimum order quantity should be confirmed in writing because it can vary between ready stock and scheduled production. Lead time should also be separated into material preparation time, quality release time, and transportation time. As a practical planning point, I ask suppliers to state the expected dispatch window in business days, but I do not treat any quoted schedule as guaranteed until stock status, documentation, payment terms, and shipping route are confirmed.

For repeat procurement, I compare total sourcing cost rather than unit price alone. A lower price may be less attractive if the supplier cannot provide consistent COAs, stable packaging, responsive technical communication, or dependable replenishment. I also ask whether a pre-shipment sample, document review, or small qualification order is available before committing to a larger quantity.

Supplier Evaluation Checklist

Technical and Quality Questions

1. Can the supplier confirm the product identity as 3,4,5-trifluorophenylboronic acid and CAS 143418-49-9?
2. What assay or purity specification is offered, and which analytical method supports the result?
3. Will the COA be issued for the actual shipped batch rather than a generic template?
4. Can the supplier provide an SDS suitable for the destination country or region?
5. What are the available package sizes, storage conditions, and recommended retest approach?

Commercial and Supply Questions

1. Is the material in stock, reserved, or produced after order confirmation?
2. What is the MOQ, expected lead time, and quotation validity period?
3. Can the supplier support repeat orders with comparable specifications?
4. Which Incoterms, payment terms, and shipping methods are available?
5. Are export documents, labels, and outer-package details available before dispatch?

How Maison Chemical Supports Procurement Teams

At Maison Chemical, I approach this product as a documented B2B chemical supply requirement rather than a simple catalog transaction. I can help organize product identification, specification review, COA and SDS confirmation, packaging discussion, quantity-based quotation, and shipment coordination. When a customer shares the intended application and destination, I can direct the inquiry toward the technical and commercial details that matter most.

For a new supplier qualification, I recommend starting with the required quantity, target purity or specification, preferred package size, destination, and documentation expectations. If the material will be used in a sensitive synthetic route, I also encourage the buyer to identify any critical impurity or moisture requirements before quotation. This information allows Maison Chemical to assess availability and provide a more useful supply proposal without making unsupported claims about suitability.

Conclusion and Next Steps

3,4,5-Trifluorophenylboronic acid CAS 143418-49-9 can be a useful aryl boronic acid intermediate for research and development routes that require a trifluorinated aromatic building block. The most reliable buying decision combines identity confirmation, documented purity, a lot-specific COA, a current SDS, suitable packaging, and a realistic review of MOQ and lead time. I recommend qualifying the supplier and documentation before treating a quoted price as the final purchasing criterion.

To begin an inquiry with Maison Chemical, prepare your required quantity, target specification, delivery destination, package preference, and document list. I can then help confirm the available supply route, review the requested COA and SDS expectations, and coordinate a quotation for laboratory, pilot, or bulk purchasing. This step-by-step approach gives procurement, R&D, and quality teams a clearer basis for approving 3,4,5-trifluorophenylboronic acid for their next project.

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