3,4-Dichlorophenylboronic Acid CAS 151169-75-4: Uses, Specifications, and Supplier Guide

3,4-Dichlorophenylboronic acid, CAS 151169-75-4, is an aryl boronic acid used primarily as a building block in palladium-catalyzed cross-coupling, especially Suzuki–Miyaura reactions. Its two chlorine substituents can influence the electronic and steric properties of the aromatic ring while remaining available for further synthetic planning. In practical procurement, I recommend evaluating identity, assay, impurity profile, packaging, documentation, and supply continuity together rather than selecting on price alone.

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This guide explains where the compound fits in organic synthesis, which specifications buyers should request, how to compare suppliers, and what information should be confirmed before an order. Because commercial grades and production routes can vary, I distinguish established chemical characteristics from product-specific data that must be verified in a current specification sheet or certificate of analysis.

Who This Guide Is For

I prepared this guide for medicinal chemistry teams, process development groups, custom synthesis companies, pharmaceutical and agrochemical researchers, and distributors sourcing specialty organic boronic acids. It is also relevant to purchasing teams that need to convert a research requirement into a clear RFQ. The most useful decisions depend on the intended reaction, required scale, acceptable impurity profile, and delivery schedule.

This material may be suitable for early route exploration, analog generation, intermediate preparation, and other laboratory-scale synthetic programs. It should not be treated as a substitute for a validated process, safety assessment, or regulatory review. Before use in a regulated or commercial application, I recommend confirming the buyer’s internal requirements and obtaining batch-specific documentation.

Basic Chemical Context

3,4-Dichlorophenylboronic acid contains an aromatic boronic acid group and two chlorine atoms located at the 3 and 4 positions of the phenyl ring. The commonly used molecular formula is C₆H₅BCl₂O₂, with a calculated molecular weight of approximately 205.83 g/mol. The compound is identified by CAS 151169-75-4, but a CAS number alone does not confirm the grade, assay, water content, or impurity level of a particular batch.

As an aryl boronic acid, it can participate in carbon–carbon bond formation with suitable aryl or vinyl halides under appropriate Suzuki–Miyaura coupling conditions. The chlorine atoms may be useful in route design because they can alter ring electronics and may provide additional synthetic handles depending on the reaction sequence. Actual reactivity depends on the coupling partner, catalyst system, base, solvent, temperature, concentration, and work-up procedure.

Uses and Application Matching

Cross-Coupling and Intermediate Synthesis

The primary use of 3,4-dichlorophenylboronic acid is as an aromatic coupling partner for preparing substituted biaryl, heteroaryl–aryl, and related structures. Researchers may select it when a 3,4-dichlorophenyl fragment is required in a target molecule. It can therefore support medicinal chemistry libraries, reference standards, advanced intermediates, and route scouting.

For a coupling project, I would first compare the compound with the required reaction map rather than assuming that every aryl boronic acid will behave identically. The identity of the electrophile, the sensitivity of other functional groups, and the desired position of bond formation all affect suitability. A small-scale compatibility experiment is generally more reliable than selecting conditions from a name or structure alone.

Research, Pharmaceutical, and Agrochemical Programs

The compound can be considered for research programs that require chlorinated aromatic fragments, although the final application depends on the target structure and downstream evaluation. In pharmaceutical discovery, it may serve as one component in the preparation of analogs or intermediates. In agrochemical research, the same type of building-block logic may apply, but commercial use requires additional process, toxicology, registration, and quality assessments.

I do not recommend describing this material as an active pharmaceutical ingredient, pesticide, or finished-use product unless the buyer has separately established that status. Its normal procurement role is as a chemical intermediate or research reagent. The buyer should define the intended use before requesting packaging, documentation, and compliance support.

Specifications Buyers Should Request

A useful specification should cover more than a nominal product name. At minimum, I recommend requesting the chemical name, CAS number, molecular formula, molecular weight, appearance, assay method, impurity limits, residual solvents where relevant, water content where relevant, and storage guidance. The supplier should identify which values are guaranteed specifications and which are typical or informational values.

The theoretical molecular weight of approximately 205.83 g/mol can help with stoichiometric calculations, but it does not replace an assay value when weighing material for a reaction. If a project is sensitive to moisture, I would specifically ask whether water content is tested and reported. If the product will enter a controlled process, I would also request representative analytical data before approving a larger quantity.

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How to Select the Right Commercial Grade

Step 1: Define the Intended Reaction

Start by recording the target bond, coupling partner, expected scale, and functional groups present in the reaction mixture. State whether the material is for route discovery, process development, analytical reference work, or a larger controlled synthesis. This information allows the supplier to discuss an appropriate grade without making assumptions about the application.

Step 2: Set Quality and Documentation Requirements

Next, define the minimum acceptable assay, impurity limits, packaging size, and required documents. A research group may prioritize fast sampling and flexible quantities, while a process team may place greater emphasis on lot consistency, traceability, and change notification. I recommend putting these requirements in the RFQ so that quotations can be compared on equivalent terms.

Step 3: Check Packaging, Storage, and Logistics

Ask how the material is packaged, whether the container is suitable for the intended quantity, and what storage conditions are recommended. Confirm available pack sizes in grams or kilograms, export documentation, shipping classification if applicable, and the proposed lead time. Do not assume that a supplier’s standard pack or delivery window will match your project schedule.

Step 4: Review a Current Batch Record

Before approving a larger purchase, request a current certificate of analysis or representative batch data. Compare the stated analytical method with your internal acceptance criteria and ask how out-of-specification events are managed. When the application is sensitive, a sample evaluation can provide useful evidence before committing to a production quantity.

Pricing, MOQ, and Lead-Time Considerations

Pricing for specialty organic boronic acids can vary with quantity, assay requirement, packaging, documentation, production status, and shipping destination. A small research pack may have a higher unit cost than a larger order because synthesis, testing, filling, and administrative costs are distributed differently. I recommend requesting tiered pricing for at least two or three quantities instead of comparing only one pack size.

Minimum order quantity should be discussed together with available inventory and manufacturing options. Stock material may support a shorter delivery schedule, while a made-to-order batch may provide a better fit for quantity or specification requirements but require additional planning. Because lead time is product- and destination-dependent, I recommend asking for a written estimate in business days and confirming whether it begins after order approval, payment, or technical confirmation.

For international sourcing, the total landed cost may include packaging, freight, customs handling, insurance, taxes, and local compliance work. These items can materially change the result of a low unit-price quotation. A practical comparison should therefore include product cost, documentation cost, delivery terms, expected yield impact, and the cost of replacing a failed or delayed batch.

Supplier Evaluation Checklist

When I evaluate a supplier, I look for clear answers rather than broad marketing claims. The supplier should be able to identify the material unambiguously, explain the available grade, provide appropriate documentation, and state which data are batch-specific. It is also useful to understand how the supplier handles technical questions, sample requests, packaging changes, and repeat orders.

• Does the quotation clearly state CAS 151169-75-4 and the requested product name?
• Are assay, impurity, appearance, and testing methods defined?
• Can the supplier provide a current SDS and batch-specific COA?
• Are quantity breaks, MOQ, pack sizes, and estimated lead time transparent?
• Can the supplier discuss custom specifications without promising unverified results?
• Are shipping, export, labeling, and document requirements addressed early?
• Is there a clear process for sample review, technical questions, and repeat sourcing?

How Maison Chemical Can Support Your Inquiry

At Maison Chemical, I approach 3,4-dichlorophenylboronic acid as a specification-led sourcing request. We can organize an inquiry around the CAS number, required quantity, target assay, packaging preference, destination, and intended use. This helps separate a standard research requirement from a project that needs additional technical discussion or documentation review.

For an efficient quotation, please provide the desired quantity in grams or kilograms, whether a sample is needed, your minimum quality requirements, and your requested delivery location. If you have an internal specification, share it with the inquiry so the proposed material can be assessed against the actual requirement. Any availability, lead-time, or quality statement should be confirmed for the specific order rather than assumed from a general product listing.

Key Takeaways and Next Steps

3,4-Dichlorophenylboronic acid CAS 151169-75-4 is an aryl boronic acid building block used mainly for planned synthetic transformations such as Suzuki–Miyaura coupling. Its approximate molecular weight is 205.83 g/mol, while the two chlorine substituents define an important part of its structure and application value. The correct commercial choice depends on verified identity, assay, impurities, documentation, packaging, and supply conditions.

My recommended next step is to prepare a concise RFQ containing the CAS number, quantity, intended use, quality target, delivery destination, and documentation requirements. Review a current specification and COA before placing a larger order, and use a sample or small-scale assessment when reaction performance is critical. Contact Maison Chemical with these details so we can discuss a practical supply option for your organic boronic acid project.

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