Quick Summary for Buyers

• Product: 3,5-Difluorophenylboronic acid
• CAS number: 156545-07-2
• Primary role: Fluorinated aryl boronic acid for carbon–carbon bond formation
• Common use: Suzuki–Miyaura coupling and medicinal or materials chemistry research
• Key purchasing checks: Assay, water content, residual solvents, appearance, analytical data, packaging, MOQ, and lead time

In practical terms, I recommend treating this material as a project-specific reagent rather than selecting it only by name and CAS number. A clear specification, batch documentation, and compatibility with the planned reaction are more important than a low unit price alone. Buyers should also confirm whether they need research quantity, kilo-scale supply, or a recurring manufacturing program before requesting a quotation.

What Is 3,5-Difluorophenylboronic Acid?

3,5-Difluorophenylboronic acid is an aryl boronic acid containing two fluorine atoms on a phenyl ring and a boronic acid functional group. The boronic acid group can participate in palladium-catalyzed cross-coupling with suitable aryl or vinyl halides, allowing chemists to construct substituted biaryl and related carbon frameworks. The two fluorine substituents can influence electronic properties, lipophilicity, metabolic behavior, and downstream molecular design, although the actual effect depends on the complete target structure.

From a procurement perspective, the CAS number helps identify the intended substance, but it is not a complete quality specification. I advise buyers to compare the product name, CAS number, molecular formula, molecular weight, structural representation, assay method, and batch-specific analytical results. This approach reduces the risk of receiving an isomer, an incorrectly labeled derivative, or material whose physical condition is unsuitable for the planned process.

Core Chemical Information

Applications and Technical Value

Suzuki–Miyaura Cross-Coupling

The most established application is use as an aryl partner in Suzuki–Miyaura coupling. In a suitable reaction system, the boronic acid can react with an aryl, heteroaryl, or vinyl halide to form a new carbon–carbon bond. Reaction performance depends on the catalyst, base, solvent, temperature, substrate structure, concentration, and work-up conditions, so I do not recommend assuming that one standard procedure will work for every project.

This building block is useful when a synthesis requires a difluorinated aromatic segment while preserving a coupling handle for late-stage diversification. It may be incorporated into intermediates for pharmaceutical discovery, agrochemical research, specialty materials, and other fine-chemical programs. The value is often greatest during route exploration, where a small structural change can help researchers compare biological, physical, or electronic properties.

Medicinal and Agrochemical Research

Fluorinated aromatic groups are frequently evaluated in medicinal and agrochemical design because fluorine substitution can alter molecular properties. However, the presence of fluorine does not by itself establish a biological advantage, regulatory suitability, or improved performance. I therefore present 3,5-difluorophenylboronic acid as a synthesis tool and intermediate, not as a finished active ingredient or proof of performance.

Materials and Building-Block Chemistry

Researchers may also use this compound to prepare functionalized aromatic molecules for materials screening or specialty organic synthesis. The boronic acid group provides a convenient point for coupling, while the difluorophenyl group can contribute a different electronic environment from non-fluorinated analogues. The suitability of the compound should be confirmed through laboratory evaluation, especially where scale-up, stability, or purification behavior is important.

Specifications Buyers Should Review

A commercial specification should be agreed before purchase, particularly when the material will enter a regulated development process or a multi-step manufacturing route. At minimum, I recommend reviewing appearance, identification, assay, related substances, water content, residual solvents, and batch traceability. The exact acceptance limits should be based on the buyer’s application, analytical method, and quality system rather than copied without technical review.

Goto Maison Chemical to know more.

Buyers should request a current certificate of analysis for the relevant batch, together with an SDS and available analytical information such as HPLC, NMR, or other appropriate identity data. I avoid presenting a universal purity value or fixed physical specification when it has not been confirmed for a particular production batch. If the project requires a defined assay threshold, buyers should state that requirement during the quotation stage.

How to Select the Right Product and Supplier

Step 1: Define the Intended Use

First, I ask whether the material is needed for exploratory synthesis, process development, analytical reference work, or commercial manufacturing. These uses can require different packaging, documentation, testing depth, and quantity. A research chemist may need a small pack quickly, while a process team may prioritize batch consistency, impurity mapping, and repeat supply.

Step 2: Match the Quality Requirement

Next, define the minimum assay, impurity profile, moisture requirement, and documentation package. If the compound will be used in a sensitive coupling reaction, water and residual solvent controls may deserve particular attention. If the material will be qualified as a raw material, the buyer should also evaluate change control, traceability, sampling procedures, and the supplier’s ability to maintain consistent specifications.

Step 3: Compare Total Procurement Risk

Price is only one part of the purchasing decision. I recommend comparing quoted price, available quantity, MOQ, lead time, packaging format, shipping conditions, analytical support, and communication speed. For example, a supplier offering a 1 kg pack may not be the best fit if the project only requires 25 g and has a short stability window.

Lead time and MOQ are not universal product constants; they depend on stock position, batch planning, production scale, testing requirements, and destination. Buyers should request these items in writing for the required quantity. A supplier that clearly separates stock material from made-to-order material can help the buyer plan more accurately.

Common Buying Mistakes

• Choosing by product name without checking the CAS number and structural identity.
• Assuming that all suppliers use the same assay or impurity calculation method.
• Requesting a quotation without stating quantity, destination, packaging, and documentation needs.
• Ignoring water content or residual solvents when the reaction is sensitive to either factor.
• Evaluating only the initial price instead of the cost of delays, re-testing, or failed reactions.

Maison Chemical Supplier Support

At Maison Chemical, I support buyers by clarifying the product identity, intended application, quantity, packaging preference, and documentation requirements before quotation. We can discuss whether the request is for laboratory evaluation, route development, or a larger supply program. This helps align the commercial offer with the buyer’s actual technical and scheduling needs.

Our support may include product information, SDS and batch-related documentation where available, packaging discussions, export coordination, and communication about stock or production scheduling. Because availability and specifications can vary by batch, I encourage buyers to provide their target quantity and required delivery date rather than relying on a generic catalog assumption. For projects with repeat demand, we can also discuss a supply plan based on forecasted consumption.

Recommended Next Steps

1. Confirm that 3,5-difluorophenylboronic acid, CAS 156545-07-2, matches the intended synthetic route.
2. Define the required quantity, assay expectation, packaging, destination, and delivery window.
3. Request the available certificate of analysis, SDS, and relevant analytical information.
4. Review water, residual solvent, impurity, and storage requirements with the technical team.
5. Compare suppliers based on quality evidence, supply continuity, communication, and total procurement risk.

The direct answer is that 3,5-Difluorophenylboronic acid CAS 156545-07-2 is primarily a fluorinated aryl building block for cross-coupling and related organic synthesis. Its suitability depends not only on the chemical name, but also on batch quality, reaction requirements, documentation, quantity, and delivery conditions. If you are evaluating this product for a new project or repeat supply, contact Maison Chemical with your required quantity and specification so we can prepare a practical B2B quotation and support the next technical review.