4-Pyrazoleboronic Acid Pinacol Ester CAS 269410-08-4: A Guide to Uses, Specifications, and B2B Procurement

I use 4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 as the standard reference name for a pyrazole-based boronic ester intermediate used primarily in synthetic chemistry. Its key value is the boronic ester group, which can participate in palladium-catalyzed cross-coupling reactions to help introduce a pyrazole-containing fragment into more complex molecules. For B2B purchasing, I recommend evaluating identity, assay, analytical documentation, packaging, delivery conditions, and supplier responsiveness together rather than selecting only by price.

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Maison Chemical supplies pharmaceutical intermediates and specialty chemical products for research, process development, and commercial sourcing discussions. Because specifications and availability can vary by batch and order scale, I recommend confirming the current product specification, CoA, SDS, packaging, and lead time before placing a purchase order.

Who This Guide Is For

This guide is intended for pharmaceutical and agrochemical development teams, medicinal chemistry laboratories, custom synthesis companies, procurement managers, and distributors evaluating CAS 269410-08-4. It is also useful for buyers comparing catalog material with a more structured B2B supply arrangement. I focus on practical decisions that affect synthesis performance, documentation, and supply continuity.

The guide is not a substitute for a project-specific risk assessment or an approved quality specification. Instead, I use it to explain what the material is, where it may fit, which documents should be requested, and how buyers can reduce avoidable procurement risks.

Basic Chemical Context

Identity and Molecular Information

4-Pyrazoleboronic acid pinacol ester is commonly described as a pinacol-protected pyrazole boronic acid derivative. The material contains a pyrazole ring and a cyclic boronic ester functionality, making it suitable as a building block in routes that require controlled carbon–carbon bond formation. The listed CAS number is 269410-08-4.

The commonly associated molecular formula is C₉H₁₅BN₂O₂, with a molecular weight of approximately 194.04 g/mol. On a theoretical basis, 1.00 g of material corresponds to approximately 5.15 mmol before purity adjustment. I advise buyers to confirm the molecular formula and molecular weight shown on the supplier’s current CoA because nomenclature, solvates, hydrates, or database records can occasionally differ.

Uses and Application Scenarios

Cross-Coupling and Medicinal Chemistry

The principal application is use as a boronic ester coupling partner in the preparation of substituted pyrazole compounds. In suitable reaction systems, the boronic ester can be combined with an appropriate aryl, heteroaryl, or vinyl halide under palladium-catalyzed coupling conditions. The exact reaction outcome depends on the substrate, catalyst, base, solvent, temperature, water content, and work-up procedure.

Medicinal chemistry teams may use this intermediate when they need to add a pyrazole unit during analog synthesis. It can support the preparation of compound libraries, lead optimization candidates, and route scouting intermediates. However, I do not recommend assuming that every substrate will show the same conversion or selectivity; small-scale screening is normally appropriate before process commitment.

Process Development and Custom Synthesis

Process chemists may evaluate CAS 269410-08-4 as one step in a longer active pharmaceutical ingredient or advanced intermediate route. Its protected boron functionality can offer a practical handling format compared with an unprotected boronic acid, although hydrolytic stability and reaction compatibility still require project-specific assessment. The most useful purchasing decision is therefore linked to the intended reaction and downstream purification strategy.

Custom synthesis organizations may also purchase the compound for route development, impurity investigation, or preparation of research quantities. For these applications, consistent identity data and lot traceability can be as important as nominal assay. I encourage buyers to state the intended use when requesting a quotation so the supplier can propose suitable documentation and packaging.

Specification Overview

What to Check on the Product Specification

A high numerical purity value alone does not fully describe material suitability. I recommend checking how the supplier defines purity, which analytical method is used, and whether the CoA corresponds to the exact lot being shipped. For development work, a buyer may also request chromatograms or additional analytical information when the route is sensitive to closely related impurities.

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How to Select the Right Material

Step 1: Define the Intended Use

First, I identify whether the material is intended for discovery chemistry, process development, registration-support work, or routine manufacturing. Each stage may require a different level of documentation, impurity control, and supply planning. A discovery project may prioritize fast access to a small quantity, while a process project usually requires stronger lot consistency and a clearer change-control approach.

Step 2: Match the Specification to the Route

Next, I compare the proposed specification with the reaction’s actual sensitivity. Important questions include whether residual solvents could affect the catalyst, whether water content may influence the coupling, and whether a trace impurity could carry into a downstream intermediate. I also check whether the buyer needs a research-grade material or a specification designed for a more controlled development process.

Step 3: Review Documentation Before Ordering

Before purchase, I request the current CoA and SDS, together with the product specification and available batch information. If the material is for a regulated or quality-sensitive project, I also ask about manufacturing site information, traceability, change notification, and the supplier’s approach to retained samples where applicable. These questions should be resolved before shipment rather than after an unexpected analytical result.

Step 4: Confirm Quantity, Packaging, and Delivery

Quantity should be calculated from the synthetic route, expected yield, sampling needs, and repeat-batch requirements. Buyers often compare a 1 g laboratory quantity with a 10 g or 100 g development quantity, but the appropriate pack size depends on the project and the supplier’s current inventory. I recommend confirming whether the quoted lead time applies to stock material, production material, or a customized batch.

Pricing, MOQ, and Lead-Time Considerations

The price of CAS 269410-08-4 can vary with quantity, purity requirement, packaging, analytical testing, shipping destination, and whether the material is available from stock. A low unit price may not represent the lowest total procurement cost if the order requires additional testing, special packaging, or a long production schedule. For this reason, I compare the complete quotation rather than only the price per gram.

Minimum order quantity is usually a commercial matter and may differ between laboratory, development, and larger-volume requests. Lead time should also be confirmed in writing because it can depend on inventory status, batch release, testing, and export arrangements. When planning a route campaign, I recommend allowing time for document review and incoming quality control instead of scheduling synthesis immediately after the estimated shipping date.

Common Procurement Mistakes

• Relying only on the CAS number: The CAS number supports identification, but buyers should still confirm the name, formula, molecular weight, and analytical data.
• Confusing purity with assay: A chromatographic purity result and a quantitative assay are not necessarily interchangeable.
• Ignoring packaging: Boronic ester intermediates should be shipped in packaging appropriate for the supplier’s stated handling requirements.
• Requesting a quotation without project details: Quantity, destination, required documents, and target delivery date directly affect the commercial offer.
• Skipping an incoming check: The receiving laboratory should verify the lot against its internal acceptance procedure before use.

Supplier Evaluation Checklist

When I evaluate a supplier, I look for clear communication, consistent product naming, technically coherent documentation, and an ability to explain what is included in the quotation. I also check whether the supplier can support samples, repeat orders, export documentation, and scale-up discussions without making unsupported claims. A responsive supplier should be willing to identify which information is confirmed and which details require batch-specific confirmation.

Maison Chemical approaches CAS 269410-08-4 as a B2B sourcing project rather than a simple catalog transaction. We can discuss the intended application, target quantity, specification expectations, packaging, documentation, and delivery destination before preparing a quotation. Availability, price, and lead time remain subject to current production and logistics conditions, so I recommend requesting an updated offer for each procurement cycle.

Key Takeaways

• 4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 is a pyrazole-containing boronic ester intermediate commonly considered for cross-coupling chemistry.
• The commonly associated molecular weight is approximately 194.04 g/mol, but buyers should verify the current supplier documentation.
• Application suitability depends on the reaction substrate, catalyst system, moisture sensitivity, impurity profile, and downstream purification.
• A complete B2B evaluation should include identity, purity method, CoA, SDS, packaging, MOQ, lead time, and traceability information.
• Maison Chemical can support quotation discussions for research, development, and broader sourcing requirements, subject to product and batch confirmation.

Conclusion and Next Steps

For buyers asking whether 4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 is suitable for a project, the answer is that it is a relevant building block when the route requires introduction of a pyrazole fragment through boronic ester coupling chemistry. The correct purchasing choice depends not only on the chemical name, but also on verified analytical data, specification fit, quantity, documentation, and delivery planning. I recommend confirming these points before approving the material for synthesis.

To begin a B2B inquiry with Maison Chemical, provide the required quantity, application stage, target specification, destination, packaging preference, and requested documents. We can then review the requirement and prepare a current quotation with available product information, commercial terms, and estimated lead time. This structured approach helps buyers make a practical decision while reducing avoidable quality and supply risks.

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