Sep. 15, 2026
Chemicals
CAS 7789-75-5 identifies dicalcium phosphate dihydrate, commonly written as calcium hydrogen phosphate dihydrate or CaHPO4·2H2O. Its relative molecular mass is approximately 172.09 g/mol, and its principal components are calcium, phosphate, and crystallization water. I recommend selecting this material by application grade, particle characteristics, purity requirements, documentation, and supply consistency rather than by CAS number alone.
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Dicalcium phosphate dihydrate is used in pharmaceutical formulations, nutritional products, food applications, animal nutrition, oral-care products, and selected technical formulations. The correct specification depends on the intended use, processing method, regional regulations, and the buyer’s internal quality system. At Azeal Materials, we help industrial buyers clarify these requirements before discussing a suitable supply option and commercial quotation.
Dicalcium phosphate dihydrate is an inorganic calcium phosphate salt containing two water molecules in its crystalline structure. It is generally supplied as a white or nearly white powder, although appearance can vary with manufacturing conditions, particle engineering, and grade. The compound is often described as relatively stable under normal dry storage, but moisture exposure and unsuitable handling can affect flow, agglomeration, and processing behavior.
Its chemical identity is important because dicalcium phosphate dihydrate is not interchangeable in every process with anhydrous dicalcium phosphate or other calcium phosphate forms. The dihydrate form contains bound water and may show different bulk density, compaction behavior, hydration behavior, and processing performance. For this reason, a buyer should specify the required hydrate form explicitly in the purchase inquiry.
In formulations, dicalcium phosphate dihydrate may provide calcium and phosphate while also contributing solid volume and powder structure. In tablet manufacturing, selected grades can be used as a diluent or compression aid, but performance depends on particle size, morphology, blending conditions, lubricant level, and equipment. In nutrition products, the relevant factors may instead include elemental calcium content, phosphate contribution, purity, dispersibility, and regulatory acceptability.
The material is not defined by one universal performance profile. A fine powder, granular powder, and directly compressible grade can behave differently even when they share the same CAS number. Buyers should therefore evaluate a representative sample under their own formulation and process conditions.
Dicalcium phosphate dihydrate is commonly considered for solid oral dosage forms and mineral supplements. It can serve as a calcium and phosphate source or as a functional excipient in products where powder flow, compaction, and dosage uniformity are important. The final suitability must be confirmed against the applicable monograph, formulation requirements, and local regulatory expectations.
For pharmaceutical procurement, I recommend reviewing more than the stated assay. The buyer should also examine loss on drying or water-related parameters, particle-size distribution, bulk and tapped density where relevant, elemental impurities, microbial limits, and traceability. These characteristics can influence both product quality and manufacturing efficiency.
Food and feed manufacturers may use dicalcium phosphate as a mineral ingredient when the material meets the relevant grade, purity, labeling, and regulatory requirements. The required calcium-to-phosphorus balance depends on the finished product and target nutrition profile. A technical-grade material should not be assumed suitable for food, feed, pharmaceutical, or oral-care use without documented confirmation.
For nutrition applications, buyers commonly review elemental calcium, phosphorus, insoluble matter, moisture, heavy metals or other specified impurities, and microbiological requirements. The exact test list should be aligned with the destination market and the customer’s quality agreement. Azeal Materials can review these requirements before supply discussions proceed.
Calcium phosphate materials are also used in certain oral-care and technical formulations. In these applications, particle size, whiteness, surface characteristics, abrasivity, dispersibility, and compatibility with other ingredients may be more important than a general chemical description. A buyer should request application-specific information rather than relying only on a standard product name.
The first distinction is between dicalcium phosphate dihydrate and related calcium phosphate materials. Dicalcium phosphate anhydrous contains no crystal water, while monocalcium phosphate and tricalcium phosphate differ in calcium-to-phosphate ratio, acidity, solubility behavior, and application profile. These materials may be suitable for different formulations, but they should not be substituted without technical evaluation.
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The second distinction is grade and physical form. Manufacturers may offer powder or more granular material, with different particle-size distributions and flow properties. Some buyers need a fine material for dispersion, while others prefer a coarser or engineered grade for improved handling and reduced dust. The appropriate option depends on the production line, dosage form, blending process, and packaging system.
| Buyer Parameter | Why It Matters | What to Confirm |
|---|---|---|
| Chemical identity | Prevents substitution with another calcium phosphate | CAS 7789-75-5, formula, hydrate form |
| Assay and elemental content | Supports formulation and nutrition calculations | Assay basis, calcium, phosphorus, test method |
| Moisture or water content | Can affect stability, flow, and compaction | Test method, acceptance range, reporting basis |
| Particle size and density | Influences blending, filling, and compression | D-values, sieve data, bulk density where required |
| Impurity profile | Supports safety and regulatory review | Specified metals, insoluble matter, and other limits |
| Documentation | Improves release and supplier qualification | SDS, COA, specification, batch traceability |
Start by stating whether the material is intended for pharmaceutical, nutraceutical, food, feed, oral-care, or technical use. This determines the relevant regulatory framework, testing expectations, packaging, and documentation. A clear end-use statement also helps suppliers avoid offering a technically similar but unsuitable grade.
Separate mandatory requirements from preferred characteristics. Mandatory requirements may include chemical identity, assay, impurity limits, microbiological criteria, and a specific hydrate form. Preferred characteristics may include a target particle-size range, improved flow, low dust, particular bulk density, or a defined packaging format.
Review how the powder will be received, stored, blended, compressed, dispersed, or filled. Particle-size distribution and bulk density can influence segregation and dosing, while moisture-related behavior can affect storage and processing. I recommend conducting a sample trial before approving a material for routine production, especially when the formulation or equipment is sensitive to powder behavior.
Request a current certificate of analysis, specification sheet, safety data sheet, batch information, and available sample details. Confirm whether the stated results are typical values or release limits, because those categories are not equivalent. Also ask about packaging, palletization, minimum order quantity, production schedule, export documentation, and delivery terms.
The price of CAS 7789-75-5 depends on grade, order volume, packaging, test requirements, destination, and current logistics conditions. A low quoted price may not represent the lowest total procurement cost if additional testing, repacking, import handling, or repeated qualification is required. Buyers should compare offers on a delivered and documented basis.
Minimum order quantity and lead time are also application-dependent. Standard stock, custom particle-size requirements, special packaging, and additional analytical testing can produce different timelines. Azeal Materials can review the requested quantity, destination, grade, and documentation package to prepare a more realistic commercial response.
A dependable supplier should be able to discuss both chemical compliance and practical supply execution. This includes responding clearly to technical questions, maintaining traceable batch information, and distinguishing confirmed data from typical or expected performance. During qualification, buyers should retain their own approval records and make the final decision according to their internal quality procedures.
At Azeal Materials, we approach CAS 7789-75-5 as a specification-matching and supply-planning requirement rather than a simple catalog purchase. We can discuss the intended application, required grade, key quality parameters, packaging preference, order quantity, destination, and documentation needs. This helps create an inquiry that is specific enough for meaningful technical and commercial evaluation.
For repeat procurement, we also encourage buyers to define the approved specification before placing regular orders. A documented target can reduce misunderstandings about hydrate form, particle size, assay basis, and testing requirements. Where a sample is appropriate, the buyer can evaluate the material in its own process before moving toward routine supply.
CAS 7789-75-5 is dicalcium phosphate dihydrate, a versatile calcium phosphate material used across pharmaceutical, nutrition, food, feed, oral-care, and technical applications. The best product choice depends on the end use, grade, chemical and physical specifications, regulatory expectations, and supply requirements. The CAS number confirms identity, but it does not by itself confirm application suitability.
For your next step, prepare the intended use, target quantity, destination market, required specification, packaging format, and documentation list. Then request a product specification, current COA example, SDS, sample availability, MOQ, and estimated lead time. Contact Azeal Materials with these details so we can evaluate the requirement and discuss a suitable supply solution for CAS 7789-75-5 dicalcium phosphate dihydrate.
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