What Is 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3 Used For?

2-Fluoro-4-(trifluoromethyl)phenylboronic acid, CAS 503309-11-3, is primarily used as an aryl-boron building block in organic synthesis. Its most established role is participation in palladium-catalyzed Suzuki–Miyaura coupling, where the arylboronic acid reacts with an appropriate aryl or heteroaryl halide to form a biaryl structure. I also see it used in medicinal chemistry, pharmaceutical intermediate development, agrochemical research, and small-molecule screening because it combines a boronic acid reaction handle with both fluoro and trifluoromethyl substituents.

If you are looking for more details, kindly visit our website.

This material should generally be treated as a research and synthesis intermediate rather than as a finished active pharmaceutical ingredient. Its suitability depends on the intended reaction, the identity and quality requirements of the project, and the supplier’s documentation. At Maison Chemical, we support buyers by discussing identity confirmation, specification expectations, packaging, handling information, and commercial supply requirements before an order is finalized.

Key Takeaways

• CAS 503309-11-3 is an arylboronic acid used mainly for carbon–carbon bond formation.
• Its boronic acid group supports cross-coupling chemistry, while the fluoro and trifluoromethyl groups remain part of the resulting molecular structure.
• The compound has a commonly reported molecular formula of C₇H₅BF₄O₂ and a calculated molecular weight of approximately 207.92 g/mol.
• Buyers should confirm purity, analytical data, packaging, storage guidance, and batch availability against their own process requirements.

Principal Uses of CAS 503309-11-3

1. Suzuki–Miyaura Cross-Coupling

The principal synthetic use of 2-fluoro-4-(trifluoromethyl)phenylboronic acid is as a coupling partner in Suzuki–Miyaura reactions. In a typical transformation, the boronic acid reacts with an aryl, heteroaryl, or vinyl halide in the presence of a suitable palladium catalyst and base. The boron-containing group is replaced through the coupling process, producing a new carbon–carbon bond and incorporating the substituted fluoro-trifluoromethyl phenyl fragment into the target molecule.

This reaction is valuable because it can connect two structurally different fragments in a relatively direct step. However, reaction performance is not determined by the boronic acid alone; catalyst selection, ligand system, base, solvent, temperature, substrate compatibility, and work-up conditions can all affect the result. I therefore recommend evaluating this material together with the complete reaction design rather than assuming that a single reagent will perform identically across all substrates.

2. Pharmaceutical and Medicinal Chemistry Research

In pharmaceutical research, this compound can serve as a building block for preparing analogues during lead discovery and structure–activity relationship studies. The boronic acid group provides a convenient point for attaching the substituted aromatic fragment to another molecular component. After coupling, the fluoro and trifluoromethyl substituents remain embedded in the product and may be used by chemists when tuning molecular properties during exploratory synthesis.

Fluorinated aromatic groups are frequently considered in medicinal chemistry because fluorine substitution can change electronic, lipophilic, metabolic, and conformational characteristics. These effects are molecule-dependent and should not be interpreted as a guaranteed biological advantage. CAS 503309-11-3 is therefore best understood as a synthesis tool that enables access to fluorinated analogues, not as a compound with a predetermined therapeutic effect.

3. Pharmaceutical Intermediate Development

The material may be used during the route-development stage for pharmaceutical intermediates and advanced intermediates. Researchers can use it to investigate coupling conditions, compare alternative synthetic routes, and prepare reference compounds or process-development samples. Whether it remains in the final commercial route depends on yield, impurity profile, raw-material availability, process safety, cost, and scale-up performance.

For development work, identity and consistency are especially important. I encourage buyers to request the applicable certificate of analysis, batch-specific analytical information where available, and safety documentation before using the material in a regulated or quality-sensitive workflow. A laboratory-scale result should not automatically be treated as evidence of manufacturing-scale suitability.

4. Agrochemical and Specialty Chemical Research

Arylboronic acids are also used in the discovery and preparation of specialty molecules outside pharmaceutical development. The substituted aromatic structure of 2-fluoro-4-(trifluoromethyl)phenylboronic acid can be incorporated into candidate agrochemical molecules, functional intermediates, and other research compounds through cross-coupling or related synthetic strategies. The exact value of the building block depends on the target structure and the required downstream chemistry.

For these applications, buyers should define whether they need a research-grade sample, a repeatable development supply, or a larger commercial quantity. Different project stages can require different documentation, packaging, and release criteria. Clear communication at the quotation stage helps prevent a mismatch between material supplied and material required.

How Its Functional Groups Influence Its Use

The compound contains three chemically relevant features: an arylboronic acid group, one fluorine atom, and one trifluoromethyl group. The boronic acid is the primary reactive handle for Suzuki-type coupling and related synthetic investigations. The fluoro and trifluoromethyl substituents are structural elements that influence the electronic character and polarity profile of the aromatic ring, although their final effect must be evaluated in the complete molecule.

You will get efficient and thoughtful service from Maison Chemical.

Its commonly reported formula, C₇H₅BF₄O₂, corresponds to an approximate molecular weight of 207.92 g/mol. These identity data are useful for purchasing, stoichiometric calculations, analytical method setup, and database matching. Buyers should still compare the supplier’s specification and analytical results with the project’s required identity criteria rather than relying on molecular formula alone.

Application Scenarios and Material Options

Discovery-Scale Synthesis

For early-stage medicinal chemistry, a small package may be appropriate for preparing a limited number of analogues. The main priorities are usually confirmed identity, usable purity, practical delivery, and documentation that allows the chemist to evaluate the reagent efficiently. A buyer may not need the same packaging format or release testing depth required for process-development material.

Route Development and Scale-Up Assessment

When a synthetic route progresses toward larger quantities, the evaluation becomes broader. The team may need information about batch-to-batch consistency, impurity patterns, moisture sensitivity, packaging configuration, and replenishment capability. I recommend confirming whether the available specification can remain consistent across the quantity range required by the project.

Custom or Project-Specific Requirements

Some customers need a specific assay range, particle form, packaging size, labeling format, or documentation package. These requirements should be discussed before production or shipment because not every request can be handled under a standard stock specification. Maison Chemical can review the intended use and communicate what information and supply options are available for the project.

Key Specifications Buyers Should Confirm

No single storage condition should be assumed without checking the product label and safety data sheet. Boronic acids can be affected by moisture, temperature, packaging, and storage duration, so the buyer should follow the supplier’s stated handling instructions. I also recommend recording the received lot number and reviewing the container condition before the material enters a controlled synthesis workflow.

Buyer Selection Factors

The best supplier is not selected by price alone. Buyers should compare product identity, stated specification, analytical support, packaging, minimum order quantity, lead time, export capability, and communication quality. If the compound is needed repeatedly, supply continuity and the supplier’s ability to discuss future demand may be more important than the lowest initial quotation.

It is also useful to distinguish between a material that is technically suitable for exploratory chemistry and one that meets a formal internal or customer specification. Ask whether the quoted product is available from stock or requires production, whether the stated lead time applies to the requested quantity, and which documents will accompany shipment. These questions reduce avoidable delays during procurement and project planning.

How Maison Chemical Supports Sourcing

Maison Chemical supplies pharmaceutical intermediates and specialty chemical building blocks for research, development, and industrial procurement. For CAS 503309-11-3, I focus on matching the customer’s intended application with the appropriate specification, quantity, packaging, and documentation requirements. This approach helps buyers assess the material before committing it to a synthesis program.

When requesting a quotation, please provide the required quantity, destination country, target delivery schedule, preferred packaging, and any purity or analytical documentation requirements. If the compound will be used in a regulated development environment, it is helpful to identify the required quality system and document expectations at the beginning. We can then review availability and provide a practical supply response based on the project information received.

Conclusion: What Is CAS 503309-11-3 Used For?

2-Fluoro-4-(trifluoromethyl)phenylboronic acid CAS 503309-11-3 is used mainly as a fluorinated aryl building block for Suzuki–Miyaura cross-coupling and related organic synthesis. Its principal applications include medicinal chemistry, pharmaceutical intermediate development, agrochemical research, and specialty molecule preparation. The compound’s boronic acid group enables molecular construction, while the fluoro and trifluoromethyl substituents provide a defined substituted aromatic fragment for the target structure.

The next step is to confirm whether the material’s identity, purity, analytical documentation, packaging, and delivery schedule match your specific synthesis plan. Contact Maison Chemical with your required quantity and specification so we can review the suitable supply option for your project.

Want more information on 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3? Feel free to contact us.