Sep. 15, 2026
Chemicals
4-tert-Butoxyphenyl boronic acid, commonly written as 4-(tert-butoxy)phenylboronic acid, is primarily used as an organic boronic acid building block in synthetic chemistry. Its most established role is as a coupling partner in palladium-catalyzed Suzuki–Miyaura reactions, where it can help introduce a protected phenoxy-substituted aryl group into more complex molecules. At Maison Chemical, we supply this intermediate for pharmaceutical research, medicinal chemistry, agrochemical development, specialty materials, and other laboratory or process-development applications, subject to the buyer’s required specification and intended use.
The compound is identified by CAS No. 176672-49-4 and is generally represented by the molecular formula C10H15BO3, with a calculated molecular weight of approximately 194.04 g/mol. These identifiers help procurement, analytical, and regulatory teams confirm that the requested material matches the intended structure. Because commercial grades can differ in assay, water content, residual solvents, and physical form, buyers should evaluate the specification rather than rely on the name alone.
The principal synthetic function of this compound is participation in carbon–carbon bond-forming reactions. The boronic acid group can react with a suitable aryl or heteroaryl halide under Suzuki–Miyaura coupling conditions, commonly in the presence of a palladium catalyst and a base. This transformation is valuable because it enables chemists to assemble biaryl and heteroaryl structures that are frequently found in discovery compounds, advanced intermediates, and functional organic molecules.
The tert-butoxy substituent provides a different electronic and steric environment from an unprotected phenol. In a synthetic sequence, this feature may help preserve the oxygen-containing functionality during selected reaction steps, depending on the reaction conditions and the stability requirements of the target route. The group should not automatically be described as universally stable or universally removable; chemists should confirm compatibility through route-specific experimentation.
4-tert-Butoxyphenyl boronic acid is also used as an intermediate for preparing substituted aromatic compounds. Researchers may combine it with halogenated pyridines, pyrazines, pyrimidines, quinolines, or other aromatic electrophiles to investigate new molecular architectures. The exact product depends on the coupling partner, catalyst system, base, solvent, temperature, purification method, and scale.
For this reason, the material is usually purchased as a route-development reagent or manufacturing intermediate rather than as a finished active ingredient. Its value lies in its defined reactive handle and aromatic substituent, which can shorten the number of synthetic steps in some research programs. Actual suitability must be confirmed by the project chemist using the intended substrates and process conditions.
In pharmaceutical research, this boronic acid may be used to prepare small molecules for screening, structure–activity relationship studies, and process-route investigation. A medicinal chemist can use Suzuki coupling to vary the aryl or heteroaryl partner while retaining the tert-butoxyphenyl fragment in a compound library. This approach supports parallel exploration of molecular size, polarity, substitution pattern, and binding-related properties.
It is important to distinguish an intermediate from a pharmaceutical ingredient. CAS 176672-49-4 is not, by itself, evidence of an approved drug use, therapeutic effect, or regulatory status. Buyers should therefore describe the intended application accurately when requesting documentation, especially when the material will enter a regulated development program.
The same coupling chemistry can support research into herbicide, fungicide, insecticide, and plant-protection candidates, although the final application depends entirely on the synthesized molecule. The compound may also be considered for specialty organic synthesis involving aromatic functional materials, molecular probes, or research compounds. These uses are best understood as potential synthetic contexts rather than guaranteed commercial applications.
Aryl boronic acids are used in the preparation of conjugated and multifunctional organic structures. In materials research, a tert-butoxyphenyl fragment may be incorporated into a larger molecule designed for optical, electronic, or surface-related investigation. However, the performance of the final material cannot be inferred from the intermediate alone, so application claims should be supported by project-specific characterization.
Commercial suppliers may offer this product in different package sizes, assay ranges, and documentation formats. A research buyer may prioritize a small pack with a certificate of analysis, while a process-development team may require larger quantities, defined impurity limits, and consistent lot-to-lot performance. The appropriate grade depends on the reaction sensitivity, development stage, and analytical control strategy.
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| Specification area | Why it matters | Buyer question |
|---|---|---|
| Identity | Confirms the requested boronic acid structure | Does the documentation identify CAS 176672-49-4 and the expected analytical profile? |
| Assay and purity | Influences reaction charging and impurity control | Is the reported method appropriate for this intermediate? |
| Water and residual solvents | May affect molar calculations and moisture-sensitive steps | Are these values reported or controlled to project requirements? |
| Physical form | Affects weighing, handling, and packaging | Is the supplied material a solid or another documented form? |
The first step is to confirm the chemical identity, including the CAS number, molecular formula, and expected molecular weight. For 4-tert-butoxyphenyl boronic acid, the commonly cited molecular weight is approximately 194.04 g/mol, which can be used for preliminary stoichiometric calculations. The final charge should still be based on the supplier’s confirmed assay and the actual analytical results for the purchased lot.
Next, review the certificate of analysis and available analytical data. Depending on the supplier and grade, this may include HPLC or another assay method, NMR identity confirmation, water content, residual solvents, and appearance. We recommend that buyers define which tests are essential before placing an order, because a specification suitable for exploratory screening may not be sufficient for process scale-up.
Storage and handling should follow the supplier’s current safety data sheet and product documentation. Boronic acids can be affected by moisture, heat, contamination, and prolonged exposure to unsuitable conditions, but the practical risk depends on the specific packaging and environment. We do not recommend assigning a storage temperature or shelf life without confirming the applicable product data for the supplied lot.
A reliable supplier should be able to provide clear product identification, a current certificate of analysis, safety documentation, packaging information, and commercial terms. For technical procurement, response quality is also important: the supplier should distinguish confirmed product information from information that requires production or quality-team verification. This reduces the risk of ordering a material that is chemically similar but not identical to the intended intermediate.
For early research, buyers may need a small quantity delivered quickly with basic analytical documentation. For scale-up, they may instead require repeat-lot consistency, larger packaging, pre-shipment review, and a defined quality agreement. Lead time, minimum order quantity, export documentation, and packaging should therefore be discussed together rather than evaluated separately.
At Maison Chemical, we support B2B buyers by discussing the intended application, target quantity, required specification, destination, and documentation needs before quotation. We can help clarify whether the request concerns laboratory evaluation, route development, or a larger procurement plan. Any availability, lead time, customization, or quality commitment should be confirmed against the specific order requirements.
One common mistake is assuming that every boronic acid will behave identically in every coupling system. Catalyst selection, base, solvent, temperature, substrate sterics, and reaction time can all influence conversion and by-product formation. A second mistake is using the nominal molecular weight without accounting for assay, hydration, or the supplier’s reported composition.
Another issue is treating the tert-butoxy group as a guaranteed protecting group under all conditions. Its behavior depends on the reaction sequence and the selected deprotection conditions, so route developers should verify stability experimentally. Buyers should also avoid requesting only a generic “phenylboronic acid” product when the para tert-butoxy substituent is structurally important to the project.
In direct terms, 4-tert-butoxyphenyl boronic acid CAS 176672-49-4 is used primarily to construct more complex aromatic and heteroaromatic molecules through cross-coupling chemistry. Its combination of a reactive boronic acid group and a tert-butoxy-substituted phenyl group makes it a useful intermediate for medicinal chemistry, agrochemical research, specialty synthesis, and selected materials projects. It is not a finished drug or a guaranteed solution for every synthetic route.
The next practical step is to compare the required structure and specification with the needs of your reaction route. Ask for the current certificate of analysis, safety documentation, available quantity, packaging options, minimum order quantity, and estimated lead time. Maison Chemical can review these requirements with your procurement or technical team and prepare a B2B quotation for 4-tert-butoxyphenyl boronic acid based on your application and delivery needs.
Contact us to discuss your requirements of 4-tert-Buthoxyphenyl boronic acid CAS 176672-49-4. Our experienced sales team can help you identify the options that best suit your needs.
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