What Is Phenylboronic Acid CAS 98-80-6? Properties, Uses, and Applications

Phenylboronic acid, identified by CAS number 98-80-6, is an aromatic organoboron compound used mainly as a reagent and building block in organic synthesis. Its phenyl group is bonded to a boronic acid group, making it useful in carbon–carbon bond-forming reactions, particularly Suzuki–Miyaura coupling. The compound has the molecular formula C₆H₇BO₂ and a molecular weight of 121.93 g/mol. For procurement, buyers should confirm purity, appearance, packaging, and current lot documentation against the requirements of their process.

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Key Takeaways

• Phenylboronic acid is a versatile arylboronic acid used in synthesis and research, including Suzuki–Miyaura coupling.
• Its molecular formula is C₆H₇BO₂, and its molecular weight is 121.93 g/mol.
• Reported melting-point values are commonly around 216–219 °C; buyers should use the supplier’s current product documentation for lot-specific information.
• Application conditions, required quality, and storage or handling procedures should be evaluated against the intended process and the applicable safety documentation.

What Is Phenylboronic Acid?

Phenylboronic acid is an organic boronic acid in which a phenyl group is attached to a boronic acid functional group. Its structure is often written as C₆H₅B(OH)₂. This combination gives chemists a functional aryl building block that can participate in reactions involving carbon–boron bonds.

In commercial and laboratory settings, the material is typically described as a white or off-white solid, although appearance should be confirmed in the applicable specification. CAS 98-80-6 identifies phenylboronic acid specifically and helps distinguish it from other boronic acids or substituted phenylboronic acid derivatives. When ordering, buyers should check both the chemical name and CAS number, as similar names may refer to compounds with different substituents or properties.

Properties and Chemical Behavior

Core identification and physical properties

The molecular formula and molecular weight are useful for calculating reagent quantities and checking material identity. The melting point is commonly reported in the approximate range of 216–219 °C, but reported values may vary with measurement conditions and material quality. Treat these figures as general reference information rather than a substitute for the current specification or certificate of analysis for a particular lot.

Reactivity and handling considerations

Phenylboronic acid is valued because its boronic acid group can participate in transformations that transfer the phenyl group to another molecular fragment. In Suzuki–Miyaura coupling, it is commonly used with an organic halide or related electrophile, a palladium catalyst, and suitable reaction conditions. The result depends on the full reaction system, including solvent, base, catalyst, temperature, and substrate structure.

Boronic acids can also interact reversibly with compounds that contain suitable diol groups, which is relevant to some sensing and molecular-recognition research. This interaction depends on factors such as the molecular structures and solution conditions, so it should not be treated as a universal performance guarantee. As with other reactive chemical intermediates, users should follow the applicable safety data sheet and assess compatibility with their process.

Uses and Applications

Organic synthesis and cross-coupling

The most established application of phenylboronic acid is as a phenyl source in carbon–carbon bond-forming synthesis. Researchers and process chemists may use it to prepare biaryl compounds and other molecules that contain a phenyl-linked framework. These structures occur across many areas of chemical research, but the suitability of phenylboronic acid depends on the specific target molecule and route design.

In pharmaceutical and fine-chemical development, the compound may serve as a synthetic intermediate or research reagent. Its presence in a route does not by itself establish that a finished product is a pharmaceutical, nor does it demonstrate suitability for any regulated manufacturing process. Buyers developing a commercial process should define the required impurity profile, test methods, and documentation with their quality and regulatory teams.

Materials research and analytical studies

Phenylboronic acid and related boronic acids may be considered in research involving functional molecules, polymers, or chemical recognition systems. In these applications, the boronic acid group can contribute to reversible interactions with certain functional groups, while the phenyl unit provides an aromatic component. Researchers should evaluate the derivative and formulation required for the target design rather than assuming that the unsubstituted compound will meet every materials specification.

It may also be used in laboratory method development and reaction screening. For scale-up, users should reassess reaction performance, impurity formation, work-up, and material handling under their own process conditions. Laboratory success alone does not establish production-scale suitability.

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Forms, Grades, and Material Options

Phenylboronic acid is a defined chemical identity, but suppliers may offer different grades or specification levels. Depending on the supplier and commercial arrangement, buyers may be able to discuss purity targets, packaging formats, or documentation requirements. These options should be confirmed for the requested quantity and destination rather than assumed to be standard.

For routine research, a general-purpose specification may be sufficient if it meets the method’s needs. For route development or manufacturing evaluation, buyers may require tighter controls on assay, water content, residual solvents, or individual impurities. Such requirements should be stated clearly in the inquiry so that the supplier can confirm feasibility before an order is placed.

How to Select a Suitable Product

Match the specification to the process

Start with the role phenylboronic acid plays in your process and identify which material attributes could affect the result. Define the required assay or purity, appearance, analytical method, and any impurity limits that are important to your application. If the material will be used in a sensitive route or a regulated environment, align documentation and acceptance criteria with your internal quality procedures.

Check packaging, quantity, and documentation

Discuss the intended order quantity, packaging preference, destination, and delivery schedule with the supplier. Confirm that the product label and shipping documents identify phenylboronic acid and CAS 98-80-6. Request the available technical and safety documents, and review whether they address your organization’s requirements before confirming the purchase.

Storage and handling should follow the supplier’s label and safety data sheet. Avoid relying on generic assumptions about shelf life or storage conditions when those details have not been confirmed for the specific product and packaging. For a new process, consider a small evaluation quantity where commercially available and appropriate to your testing plan.

Supplier Support from Maison Chemical

As a chemicals manufacturer, supplier, and exporter, Maison Chemical can discuss phenylboronic acid sourcing requirements with B2B buyers. When you request a quotation, provide the target quantity, destination, required specification, packaging preference, and any documentation needs. This information helps us assess the inquiry and clarify which product details can be confirmed for the requested supply.

For technical evaluation, buyers should share relevant acceptance criteria without disclosing confidential process information. We can discuss product identity, available quality documentation, and supply options for the inquiry. Lot-specific values, lead time, and order conditions should be confirmed directly before purchase.

Conclusion

Phenylboronic acid CAS 98-80-6 is an aromatic boronic acid used chiefly as a synthetic building block, especially in Suzuki–Miyaura coupling, with additional relevance to selected research applications. Its key identifiers include the formula C₆H₇BO₂, molecular weight of 121.93 g/mol, and a commonly reported melting-point range of approximately 216–219 °C. These general facts help establish product identity, but they do not replace lot-specific documentation.

To determine whether it fits your project, define the intended use, quality requirements, quantity, and documentation needs, then verify them with the supplier before ordering. Contact Maison Chemical with your specification and sourcing requirements to discuss phenylboronic acid availability and an appropriate supply arrangement.

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